Calama se encuentra a 1.502 kilómetros de Valparaíso. La duración del viaje en promedio es de 16 horas, en categoría semi cama o cama dependiendo de la compañía de buses, las que atraviesan la Ruta 5 Norte que conecta ambas ciudades.
Sin embargo no hay buses directos por lo que se debe llegar a Santiago, para luego tomar otro hasta Valparaíso.
Los buses salen de Calama desde Terminal de Buses de Calama a o terminales/paraderos definidos por cada empresa.
En Santiago los buses llegan a Terminal San Borja o Terminal Alameda y en Valparaíso llegan a Terminal Rodoviario de Valparaíso.
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Calama is the point of arrival for those who wish to visit one of the mandatory destinations of tourists visiting Chile, San Pedro de Atacama, which has among its attractions the saltwater Laguna Cejar. Calama is one hour from San Pedro de Atacama and has a population that is mainly dedicated to mining due to the large number of mining deposits in the area, including one of the largest in Chile-Chuquicamata. Calama has prominent hotels, such as the Hotel Diego de Almagro.
Valparaíso is one of the largest cities in the country. It is the main port of the country and center of legislative power since the congress is located in its central area, just a few steps from the bus terminal of the city. It is characterized by its countless hills and viewpoints of the port, with its traditional elevators and funiculars, offering multiple options of walks to its visitors, among which Cerro Concepción, Paseo Gervasoni and the elevators Reina Victoria, Polanco and El Peral stand out. In the new year one of the largest pyrotechnic shows in the world is performed along its coast.